SATELLITE SYMPOSIUM

PHARMACOLOGICAL MODULATION OF STEROIDOGENESIS AND 

OF STEROID EFFECTS IN THE NERVOUS SYSTEM 

Saturday February 24 - Torino

Chairs: Roberto Cosimo Melcangi (Italy) and Luis Miguel Garcia-Segura (Spain)

8:45 Melcangi R.C. (Italy) Introduction to the Satellite Symposium

9:00 Rainer Rupprecht (Germany) Role of translocator protein (TSPO) as a diagnostic and therapeutic target in the nervous system 

9:30 Eleonora Da Pozzo (Italy) Steroidogenic translocator protein (TSPO) and inflammation of human microglial cells 

10:00 Vincent Prevot (France) Age-related loss of GnRH expression and rhythmic release in cognitive disorders: a role for minipuberty? 

10:30 - 11:00 coffee break

11:00 Thérèse Di Paolo (Canada) Effect of 5alpha-reductase inhibitors in animal models of Parkinson's  disease 

11:30 Luis Miguel Garcia-Segura (Spain) An overview of selective estrogen receptor modulators as neuroprotectants

12:00 George Barreto (Ireland) Unraveling the mechanisms of neuroprotection by tibolone: now and beyond 

12:30 - 14:00 lunch

14:00 Elisabeth Traiffort (France) The androgen receptor: an unexpected pharmacological target in the demyelinated central nervous system of females

14:30 Erika Comasco (Sweden) Progesterone receptor modulation: effects on the brain and mood 

15:00 Katharina Gapp (Switzerland) A novel tool to combat stress (-hormone receptor) signatures 

15:30  Jonathan Hirst (Australia) Neurosteroid analogue therapies after preterm birth and major stresses in pregnancy

16:00 Closure of the Satellite Symposium

12th INTERNATIONAL MEETING

STEROIDS AND NERVOUS SYSTEM

Saturday February 24 - Torino

16:30 Opening ceremony

SYMPOSIUM - STEROIDS AND THE GUT-BRAIN AXIS 

Chairs: Marc Tetel (USA) and Roberto Cosimo Melcangi (Italy)

17:00 Silvia Diviccaro (Italy) Gut-Microbes-Brain communication: focus on gut steroids in physiopathological conditions

17:30 Marc Tetel (USA) Estrogens, anxiety, and the gut microbiome

18:00 Chris Lowry (USA) Microbiome-gut-brain axis signaling and PTSD: Implications for prevention and treatment 

18:30 Niklas Blank (USA) The enteric nervous system relays psychological stress to intestinal inflammation

19:00 PLENARY LECTURE

Marc Claret (Spain) 

Multifaceted mitochondria in hypothalamic neurons 

Chair: George Barreto (Ireland)

20:00 Welcome Cocktail 

Sunday February 25

SYMPOSIUM - PLACENTAL STEROIDS AND NEURODEVELOPMENT 

Chairs: Anna Penn (USA) and Luis Miguel Garcia-Segura (Spain)

9:00 Anna Penn (USA) Placental steroids and neurodevelopment 

9:30 Claire-Marie Vacher (USA) Impact of placental steroid insufficiency on brain development and long-term behaviors: influence of sex

10:00 Alex Tsompanidis (UK) Sex differences in the placenta and their link to autism likelihood and neurodevelopment 

10:30 - 11:00 coffee break

11:00 Morgan Firestein (USA) Prenatal maternal steroid levels as mechanisms underlying the associations between maternal metabolic conditions and child neurodevelopment 

11:30 PLENARY LECTURE

Liisa Galea (Canada) 

Game of Hormones: why sex and sex hormones matter for brain health

Chair: Charlotte Cornil (Belgium)

12:30 - 14:00 lunch & poster session /exposition

SYMPOSIUM - HORMONAL CONTRACEPTIVES AND THE BRAIN: A FOCUS ON RODENT MODELS

Chairs: Jesse M. Lacasse (Canada) and Liisa Galea (Canada) 

14:00 Jesse M. Lacasse (Canada) Hormonal contraceptives and the developing brain: evidence from animal models 

14:30 Patrizia Porcu (Italy) How hormonal contraceptives shape brain and behavior: evidence from rodent models 

15:00 Ami P. Raval (USA) Simultaneous nicotine and oral contraceptive exposure alters brain energy metabolism and exacerbates ischemic stroke injury in female rats 

15:30 Nafissa Ismail (Canada) Understanding the effects of oral contraceptives on the adolescent and adult female brain 

16:00 - 16:30 coffee break

MINISYMPOSIUM - EXPLORING ENZYMATIC ABERRANCIES IN THE STEROIDOMIC TREE. 

IMPLICATIONS FOR SCHIZOPHRENIA PATHOPHYSIOLOGY AND PHENOTYPIC DIVERSITY

Chairs: Martin Hill (Czech Republic) and Silvia Giatti (Italy) 

16:30 Martin Hill (Czech Republic) Steroidomics in men with schizophrenia 

17:00 Karel Valeš (Czech Republic) Enzymatic changes in steroidomic pathways and neuroimaging correlates in men with schizophrenia 

17:30 Kacjaryna Mardačova (Czech Republic) Sexual perception in patients with schizophrenia: links to hormonal milieu 

Monday February 26

SYMPOSIUM - STRESS AND SEX EFFECTS ON COGNITION, PAIN, AND RELATED-PATHOLOGIES

Chairs: Christina Dalla (Greece) and Roberto Frau (Italy) 

8:30 Debra Bangasser (USA) Early life adversity causes sex- and reinforcer-specific effects on motivated behavior 

9:00 Rebecca Shansky (USA) The influence of sex-dependent pain processing in Pavlovian fear conditioning

9:30 Christina Dalla (Greece) Sex differences in depression and anxiety: estrogen membrane receptor GPER1, as a psychopharmacological target in male and female rats

10:00 - 10:30 coffee break

10:30 Ioannis Sotiropoulos (Greece) The etiopathogenic role and biomarker potential of chronic stress on Alzheimer’s disease brain pathology 

11:00 YOUNG INVESTIGATOR SYMPOSIUM

Chairs: Silvia Diviccaro (Italy) and Marilena Marraudino (Italy) 

Bautista-Abad Á. (Spain) Tibolone treatment alter traumatic brain injury exerts a sex-specific and y chromosome-dependent regulation of methylation and demethylation enzymes in the cerebral cortex

de la Vega Ruiz R. (Spain) Androgens support hippocampal-dependent memory and regulate dorsal CA1 hippocampal oscillations and excitatory-inhibitory circuits

Del Río J.P. (Chile) Hyperandrogenism during high brain plasticity periods increases negative affects and reduces prosocial behaviors: a study in adolescent daughters of women with polycystic ovary syndrome

Nayak A.R. (India) Contrasting effects of finasteride administration on male and female rats: interactions with the cholinergic system

Thaweepanyaporn K. (United Kingdom) Impact of Site-Specific Aromatase Knockdown in the Hypothalamus on Social Behaviour

Alshakhouri M. (New Zealand) Using LTP to Investigate the Neurosteroid Withdrawal Hypothesis of Perimenstrual Catamenial Epilepsy

Wren G. (United Kingdom) Memory and associated cognitive functioning in individuals with steroid sulfatase deficiency (X-linked ichthyosis)

Lee B.H. (Canada) Parity differentially influences neuroplasticity and neuroinflammation at middle age depending on APOEε4 genotype 

12:30-14:00 lunch & poster session/exposition

SYMPOSIUM - A TRIBUTE TO MARY DALLMAN: THE ENDURING EFFECTS OF GLUCOCORTICOIDS

Chairs: Seema Bhatnagar (USA) and Onno Meijer (Netherlands) 

14:00 Victor Viau (Canada) Corticosteroid-binding globulin (SERPINA6) shapes the development and sexual dimorphism of the hypothalamic-pituitary-adrenal (HPA) axis

14:30 Claire-Dominique Walker (Canada) Glucocorticoids, early stress and emotional regulation in development 

15:00 James Herman (USA) Glucocorticoid receptor signaling, stress susceptibility and stress resilience 

15:30 Seema Bhatnagar (USA) Behavioral and physiological consequences of glucocorticoid receptor regulation of the sphingosine-1-phosphate 3 receptor 

16:00 - 16:30 coffee break

MINISYMPOSIUM - GLUCOCORTICOID EXCESS: SHORT- AND LONG-TERM CONSEQUENCES 

Chairs: Rosario Pivonello (Italy) and Onno Meijer (Netherlands) 

16:30 Nikolaos Daskalakis (USA) Dissecting the brain glucocorticoid signaling involvement in PTSD and MDD using multi-omics and single cell genomics

17:00 Alberto M Pereira Aria (The Netherlands) Neurocognitive and pychiatric effects in patients with Cushing's syndrome  

17:30 Elena Valassi (Spain) Long-term effects of glucocorticoids on quality of life and survival in patients with Cushing’s syndrome 

Tuesday February 27

SYMPOSIUM - CIRCUIT MECHANISMS UNDERLYING SEX STEROID ACTION IN THE BRAIN

Chairs:  Luke Remage-Healey (USA) and Pablo Méndez (Spain) 

9:00 Luke Remage-Healey (USA) Cell-type specific regulation of auditory function by neuroestrogens 

9:30 Nicolas Gutierrez  (Portugal) In the mood for sex: hormonal regulation of female sexual receptivity

10:00 Pablo Méndez (Spain) Genetic and gonadal determination of sex hormone regulation of synaptic inhibition and hippocampal function 

10:30-11:00 coffee break

11:00 Catherine Christian-Hinman (USA) Impacts of epilepsy on neural and pituitary circuits regulating reproductive endocrine function

11:30 PLENARY LECTURE

Charlotte Cornil (Belgium) 

Role of neuroestrogens in sexual behavior from birds to mammals  

Chair:  Karyn M Frick (USA) 

12:30 - 14:30 Poster discussion & lunch 

MINISYMPOSIUM - GENDER-AFFIRMING TREATMENT FOR TRANSGENDER PEOPLE: 

SEX, GENDER IDENTITY AND SEX HORMONES EFFECTS ON THE BRAIN

Chairs:  Antonio Guillamón (Spain) and Stefano Gotti (Italy) 

14:30  Sarah Burke (The Netherlands) Hypothalamic development in cis- and transgender youth

15:00 Philippa Hüpen (Germany) Brain functional correlates of gender-specific voice processing in transgender individuals in the course of gender-affirming hormonal treatment

15:30 Antonio Guillamón (Spain) Cerebral effects of gender-affirming hormone treatments in transgender individuals

16:00 Closing of the Meeting

Enjoy Torino:

VISIT to the MUSEO NAZIONALE RISORGIMENTO ITALIANO

http://2011.museorisorgimentotorino.it/index.php?l=en

https://www.museorisorgimentotorino.it/

Social Dinner:

RISTORANTE ARCADIA

https://www.foodandcompany.com/ristorante-arcadia/